I had been running E22 alpha and beta on my desktop. I had problems with alpha on my laptop. Mostly empty GTK windows as reported in T6144. Though the issue in T6146 started occurring last night when I had the main menu open when I moused over I think Development or Graphics. Something in there seemed to crash EFM and restart, icons disappeared as did desktop background and came back. All other things remained.
Today after login and reboot a few times. The desktop continued to flicker. Icons seemed to have issues and odd things taking place on screen when over say the shelf or other stuff. I would see like shapes of the screen not being drawn or something like that, triangular shapes. Seemed like video cards issues. Till I switched back to 0.21.9 and all is well.
Not sure what is up with 0.22.0 but it has some serious issues. I would delay any release till issues can be worked out. I am unable to run that version on both my laptop and dual display desktop. That is not good.